| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 11/12/25 18:45 | FC Midtjylland | KRC Genk | 1:0 |
| 11/12/25 18:45 | PFC Ludogorets Razgrad | PAOK Salónica | 3:3 |
| 11/12/25 18:45 | FC Utrecht | Nottingham Forest | 1:2 |
| 11/12/25 18:45 | Ferencvaros Budapest | Glasgow Rangers | 2:1 |
| 11/12/25 18:45 | Young Boys Berna | OSC Lille | 1:0 |
| 11/12/25 18:45 | VfB Stuttgart | Maccabi Tel Aviv | 4:1 |
| 11/12/25 18:45 | Dinamo Zagreb | Real Betis Balompié | 1:3 |
| 11/12/25 18:45 | SK Sturm Graz | Estrella Roja Belgrado | 0:1 |
| 11/12/25 18:45 | OGC Niza | Sporting Braga | 0:1 |
| 11/12/25 21:00 | FC Porto | Malmö FF | 2:1 |
| 11/12/25 21:00 | FC Basilea | Aston Villa | 1:2 |
| 11/12/25 21:00 | Olympique Lyon | Go Ahead Eagles Deventer | 2:1 |
| 11/12/25 21:00 | Panathinaikos Athenas | Viktoria Pilsen | 0:0 |
| 11/12/25 21:00 | SC Freiburg | FC Red Bull Salzburgo | 1:0 |
| 11/12/25 21:00 | FCSB Bukarest | Feyenoord Rotterdam | 4:3 |
| 11/12/25 21:00 | R. C. Celta de Vigo | FC Bologna | 1:2 |
| 11/12/25 21:00 | Celtic Glasgow | AS Roma | 0:3 |
| 11/12/25 21:00 | Brann Bergen | Fenerbahçe SK | 0:4 |